Table 1.

Pathway analysis of gene identified as significantly changed by surgery or sex.

IPA Analysis of Differential Gene Expression by MI
Top Functions in Identified Networks	Score	Molecules in Network
	53	32
	39	26
	32	25
	32	23
	32	23
	31	23
	28	21
	19	18
	19	16
	16	16
	16	14
Organismal injury and abnormalities, molecular transport, cell death	16	14
	15	14
	14	13
	14	13
	12	12
	12	12
Tumor morphology, cellular development, nervous system development/function	11	11
	10	10
	9	11
Molecular transport, protein synthesis, protein trafficking	1	1
Cell-to-cell signaling/interaction, cell morphology, cellular development	1	1
	1	1
IPA Analysis of Differential Gene Expression by Sex
Top Functions in Identified Networks
	14	6
Neuorological disease, opthalamic disease, dermatologic diseases and conditions	3	1
	3	1
	2	1
	2	1
	2	1

Genes identified as significantly changed by surgery (500 genes, top) or sex (14 genes, bottom) were analyzed using Ingenuity Pathway Analysis (ingenuity.com). Twenty-three networks were identified from the surgery group and 6 networks were identified from the sex group. The top functions in each group are identified as well as the score (a rank ordering value, calculated by the IPA software) and number of molecules identified in the group. Commonalities in functions amongst the groups are color coded: blue for cell cycle/proliferation, red for inflammation, pink for metabolism, green for connective tissue disorders, orange for genetic disorder, and purple for cardiovascular disease.