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. 2010 Oct 15;24(20):2330–2342. doi: 10.1101/gad.1977210

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Figure 5. — Microarray experiment comparing expression of genes in hypothalami of wild-type mice and of mice lacking Creb only in VMH neurons. (A,B) Heat map of the microarray analysis of four wild-type hypothalami versus hypothalami of theee mice lacking Creb only in VMH neurons (Creb_Sf1^−/− mice). Genes significantly (P < 0.05) up-regulated (A) or down-regulated (B) in hypothalamus of Creb_Sf1^−/− mice compared with that of wild-type littermates. These genes are ordered by fold change from maximum to the threshold of 1.20. The list of the genes up-regulated or down-regulated are mentioned in the last column. (C,D) Real-time PCR (qPCR) analysis of Th (C) and Bche (D) expression in hypothalami of wild-type (WT), Creb_Sf1^−/−, Htr2c^−/−, Tph2^−/−, and Htr2c^+/−; Creb_Sf1^+/− mice at 12 wk of age.