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. 2010 Oct 15;24(20):2330–2342. doi: 10.1101/gad.1977210

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Figure 6. — CaMK/CREB signaling cascade regulates bone remodeling by inhibiting the sympathetic tone. (A,B,D) Real-time PCR (qPCR) analysis of Ucp1 expression in brown adipose tissue in wild-type (WT), CaMKKβ_Sf1^−/−, and CaMKIV_Sf1^−/− mice at 8 wk, and wild-type (WT), CaMKKβ_Sf1^−/−, CaMKKβ_Sf1^+/−, CaMKIV_Sf1^−/−, and CaMKIV_Sf1^+/− mice 12 wk of age (A), and in 12-wk-old Htr2c^+/−; CaMKKβ_Sf1^+/− and Htr2c^+/−; CaMKIV_Sf1^+/−^,− (B) and Creb_Sf1^−/−, Creb_Sf1^+/−, Adrβ2^+/−; Creb_Sf1^−/−, and Adrβ2^+/ (D) mice. Error bars represent SEM. Student's t-test (*) P < 0.05, (**) P < 0.001. (C) Histomorphometric analysis of Adrβ2^+/−; Creb_Sf1^−/− do not show any significant difference in comparison with wild-type mice for bone volume over trabecular volume (BV/TV%), number of osteoblasts per bone perimeter (Ob.N/B.Pm [number of square millimeters]), bone formation rate (BFR), osteoclast surface per bone surface (Oc.S/BS [percent]), mineral apposition rate (MAR [micrometers per day]), and CTx (nanograms per milliliter), a biomarker of bone resorption.