Table 2.

Discrimination of the effects of age (baseline) and time (years elapsed since the first visit) on DNA methylation of Alu and LINE-1 repetitive elements (change in %5Methyl-cytosine).

	Alu			LINE-1
	β*	Standard Error	p-value	β*	Standard Error	p-value
	Unadjusted
Effect of age at baseline	−.016	.006	0.007	−.017	.009	0.07
Effect of years since first visits	−.082	.015	<0.0001	−.000	.024	0.97
	Adjusted†
Effect of age at baseline	−.016	.006	0.013	−.014	.010	0.14
Effect of years since first visits	−.089	.017	<0.0001	−.018	.027	0.51

^*Regression coefficient representing the change (% 5Methyl-cytosine/year) in ALU or LINE-1 repetitive element methylation.

^†Adjusted for determinants of Alu and LINE-1 methylation, including body mass index, systolic and diastolic blood pressure, fasting blood glucose, percent lymphocytes and neutrophils in blood count, statin