Fig. 1.

Of 117 patients with C. difficile-associated diarrhea (CDAD), 111 (94.9%) received an initial treatment of metronidazole. Of these, 14 patients (12.6%) had no positive reaction. Of the responders, 13 (13.4%) experienced CDAD recurrence after successful metronidazole treatment. After failure of metronidazole failed, 10 out of 11 patients (90.9%) subsequently responded to vancomycin. In the cases of recurrence, eight out of nine patients (88.9%) responded to repeated metronidazole treatment.