FIG. 5.

Corneal epithelia are damaged by CEES and NM, and tetracycline derivatives decrease damage. Corneas that were treated for 24 h with tetracycline derivatives after a 2-h vesicant exposure were compared with unexposed and tetracycline derivative-only samples. Top row: sections from unexposed control corneas. Left column: unexposed corneas that received a 24-h treatment with tetracycline derivatives (drug-only controls). Middle column set: CEES exposure, untreated (row 2) or treated for 24 h with tetracycline derivatives (rows 3–6). Right column set: NM exposure, untreated (row 2) or treated for 24 h with tetracycline derivatives (rows 3–6). DDMT, dedimethylamino tetracycline; dox, doxycycline; t-BS, 9-t-butyl sancycline.