FIG. 7.

Hydrogels designed to release doxycycline over 24 h improved the BMZ of NM-exposed corneal cultures. (A, B) Different magnifications of unexposed corneas, showing normal morphology after hydrogels treatment for 24 h; (C, D) low and high magnifications of corneas treated with hydrogel containing doxycycline; (E, F) low and high magnification of corneas treated with hydrogel for 24 h after a 2-h NM exposure; (G–I) low and high magnifications of corneas exposed to NM, followed by treatment with a hydrogel containing doxycycline, which have an improved BMZ phenotype compared with those that received hydrogel without the drug (E, F).