Table 1.
Frequencies of causes of failures of HLA-matched and - mismatched liver transplants in patients requiring retransplantation
| No. HLA mismatches | No. transplants | Frequency of cause of failures |
||
|---|---|---|---|---|
| Rejection | Primary nonfunction | Othera | ||
| 0 HLA-DR | 13 | 15.4% | 61.5% | 23.1% |
| 1 HLA-DR | 31 | 35.5% | 29.0% | 35.5% |
| 2 HLA-DR | 64 | 50.0%b | 18.8%b | 31.3% |
| 0 HLA-A | 12 | 33.3% | 25.0% | 41.7% |
| 1 HLA-A | 46 | 43.5% | 28.3% | 28.3% |
| 2 HLA-A | 61 | 47.5% | 24.6% | 27.9% |
| 0 HLA-B | 6 | 16.7% | 16.7% | 66.7% |
| 1 HLA-B | 22 | 36.4% | 36.4% | 27.3% |
| 2 HLA-B | 91 | 48.4% | 24.2% | 27.5% |
| 0 HLA-A or 0 HLA-B | 17 | 29.4% | 23.5% | 47.1% |
| No 0 HLA-A and no 0 HLA-B | 102 | 47.1%c | 26.5% | 26.5%c |
a
Other causes of failure include vascular thrombosis, technical complications, and 4 cases of infection.
b
The differences in HLA-DR effects on rejection and primary nonfunction were statistically significant (P = 0.007).
c
The combination of zero mismatches for either HLA-A or HLA-B was associated with a lower incidence of rejection, but a higher frequency of other causes of graft failures as compared with transplants with one or more HLA-A and HLA-B mismatches. The differences between these groups were of borderline statistical significance (P = 0.082).