Table 2.
Effects of chronic ethanol and antioxidants on growth and liver pathology
| Treatment | Body wt gain1 | Liver wt2 | BEC3 | ALT4 | Steatosis5 | Inflammation5 | Necrosis5 | Total pathology6 |
|---|---|---|---|---|---|---|---|---|
| Control | 3.3 ± 0.13 | 12.4 ± 0.8 (2.8) | – | 112 ± 10 | 1.0 ± 0.01 | 1.2 ± 0.17 | 1.0 ± 0.01 | 3.2 ± 0.17 |
| Control + NAC | 4.2 ± 0.13a | 13.5 ± 0.6 (2.8) | – | 126 ± 18 | 1.0 ± 0.01 | 1.2 ± 0.17 | 1.0 ± 0.01 | 3.2 ± 0.17 |
| EtOH | 3.1 ± 0.08 | 20.5 ± 0.7 (4.8)b | 106 ± 37 | 267 ± 38b | 4.0 ± 0.25b | 3.0 ± 0.23b | 2.6 ± 0.22b | 9.4 ± 0.67b |
| EtOH + NAC | 2.1 ± 0.04c,d | 18.6 ± 0.7 (4.7)c | 109 ± 23 | 172 ± 23c,d | 3.5 ± 0.27c | 2.1 ± 0.25c,d | 1.9 ± 0.27c | 7.4 ± 0.51c |
Data are presented as means ± SE for N = 8 –13 rats/group.
Statistical significance as indicated by superscripts a–d (P < 0.05) was determined by two-way ANOVA followed by Student’s Neuman-Keuls post hoc analysis except for the pathology scores where statistical significance was determined by two-way ANOVA of Ranks followed by Dunn’s test.
a
control + NAC vs control.
b
EtOH vs control.
c
EtOH + NAC vs control + NAC.
d
EtOH + NAC vs EtOH.
1
g/day.
2
g (% body weight).
3
BEC at sacrifice, mg/dl.
4
SF units/ml.
5
Pathology score as defined under Materials and methods, normal pathology = 1.
6
Total pathology score as defined under Materials and methods, normal pathology = 3.