Table 5.

Scale up of dynamic kinetic resolution.^a

Entry	1 (mmol)	Acyl donor	Acyl donor (equiv)			8 (equiv)	ee (%)	Yield (%)b
			0 h	24 h	48 h
1	10	7	0.75	0.35	—	2.5	97	93 (90)
2	10	7	0.4	0.35	0.35	2.5	99	91
3	10	6	0.75	0.35	—	1.25	98	(74)
4c	45	6	0.4	0.35	0.35	1.25	98	(68)
5d	45	6	0.75	0.35	—	1.25	98	(83)

^aConditions: 1, 1.25 mol % of 4, 100 mg of CALB, 200 mg of Na₂CO₃, acyl donor, hydrogen donor 9, 50 mL of toluene, 100 °C, 72 h; ^bdetermined by GC, isolated yield in parenthesis; ^c225 mg of CALB, addition of 113 mg of CALB after 24 and 48 h; ^d340 mg of CALB, addition of 110 mg of CALB after 24 h.