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Biological activities of BRAF inhibitors
| No | Compound | IC50 BRAF (μM) | IC50 ppERK (μM) | GI50 SRB (μM) |
|---|---|---|---|---|
| 1a |  |
1.60 | 5.8 | 7.4 |
| 1b |  |
1.20 | 2.02 | 3.9 |
| 1c |  |
>10 | >100 | 11 |
| 1d |  |
3.7 | 10 | 4.1 |
| 1e |  |
1.84 | 5.8 | — |
| 1f |  |
1.71 | 25 | 3.3 |
| 1g |  |
>10 | 100 | 8.9 |
| 1h |  |
0.23 | 1.09 | 1.15 |
| 1i |  |
>10 | 4.4 | — |
| 1j |  |
0.24 | 0.58 | 0.87 |
| 1k |  |
1.33 | 4.9 | 36 |
| 1l |  |
3.6 | 0.74 | 1.61 |
| 1m |  |
2.15 | 0.84 | 0.94 |
| 1n |  |
2.78 | 0.97 | 1.59 |
| 1o |  |
7.5 | 0.73 | 1.91 |
| 1p |  |
>10 | >10 | — |
