Table 3.
Characteristics of Patients Who Did and Did Not Receive Empiric Antibiotics
| Antibiotics (n = 312) | No antibiotics (n = 873) | P value | |
|---|---|---|---|
| Mean age (years) a | 53.4 ± 1.06 | 56.4 ± .62 | <0.05 |
| Percent (n) male | 66.7 (208) | 60.6 (529) | NS |
| Percent (n) intubated | 82.4 (257) | 59.1 (516) | <0.001 |
| Percent (n) with history of renal failure b | 2.2 (7) | 1.9 (17) | NS |
| Percent (n) with renal failure at baseline | 9.3 (29) | 4.7 (41) | <0.05 |
| Percent (n) by admitting surgery service | |||
| Trauma | 48.4 (151) | 44.7 (390) | NS |
| General | 26.0 (81) | 19.0 (166) | <0.05 |
| Cardiothoracic/vascular | 10.3 (32) | 21.8 (190) | <0.001 |
| Percent (n) with antibiotic use and infections | |||
| Infection at admission | 6.4 (20) | 6.1 (53) | NS |
| Developed infection | 30.4 (95) | 7.8 (68) | <0.001 |
| Any infection | 36.9 (115) | 13.9 (121) | <0.001 |
| Any resistant infection | 18.9 (59) | 5.7 (50) | <0.001 |
| Mean total antibiotic days | 6.9 ± 0.35 | 2 ± 0.11 | <0.001 |
| Outcomes | |||
| Mean STICU LOS (days) | 12.7 ± 0.56 | 5.9 ± 0.19 | <0.001 |
| Mean ventilator days | 8.8 ± 0.53 | 2.4 ± 0.13 | <0.001 |
| Percent (n) developing renal failure | 22.4 (70) | 11.9 (104) | <0.001 |
| Percent (n) dying | 8.7 (27) | 3.2 (28) | <0.001 |
a
Means ± standard deviation.
b
Serum creatinine concentration >2.2 mg/dL.
NS = not significant; STICU LOS = surgical and trauma intensive care unit length of stay.