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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Aug 21;20(21):6306–6309. doi: 10.1016/j.bmcl.2010.08.076

Table 3.

In vitro activity of the (Z)-3-(2-aryl-2-oxoethylidene)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-ones

graphic file with name nihms238271t4.jpg
Compound R2’ R3’ MICa
(µg/ml)
14 H H 3.13
15 Me H 100
16 F H 3.13
17 Cl H 12.5
18 H Me >100
19 H F 1.56
20 H Cl 3.13
a

Compound concentration giving 90% inhibition of M. tuberculosis H37Rv growth.