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. Author manuscript; available in PMC: 2010 Oct 18.
Published in final edited form as: Arch Dermatol. 2008 Jul;144(7):851–858. doi: 10.1001/archderm.144.7.851

Figure 4.

Figure 4

Attenuation of antifibrotic responses with weekly high-dose UV-A1 phototherapy. Ten healthy subjects with lightly pigmented skin (L* [luminescence] >65) were treated with high-dose UV-A1 phototherapy (130 J/cm2) once per week. Biopsy samples and skin pigmentation readings were obtained 24 hours after 1, 2, and 3 weekly treatments. A and B, The indicated transcripts (type I and type III procollagen [A] and matrix metalloproteinases [MMPs] 1, 3, and 9 [B]) were assessed by real-time polymerase chain reaction. Data are presented as mean fold change relative to untreated skin (normalized to 1). In A, the horizontal dashed line indicates fold change of untreated skin. C, Skin pigmentation is shown as mean L* value. Error bars represent SEM. *P<.05 compared with untreated skin. †P<.05 compared with a single UV-A1 exposure. mRNA indicates messenger RNA.