Table 3.

Influence of splenectomy on heart graft survival in FK506-treated animals

Group	Treatment	n	Graft survival (days)	MST (days)	Pa
1b	—	7	6, 6, 6, 6, 6, 7, 7	6.0	—
2b	1.28 mg/kg, days 4, 5, 6	6	23, 51, 89, 93, 98, 146	91.0	<0.01
3	Splenectomy	3	6, 6, 6	6.0	NS
4	1.28 mg/kg, days 4, 5, 6 with  splenectomyc	9	30, 33, 37, 38, 40, 41,  136, 167d, 173d	40.0	<0.001

^aP value (Wilcoxon rank sum test) group 2 vs. 4: NS.

^bControl values from Table 1.

^cSplenectomy was performed on the day of grafting.

^dAnimal was sacrificed with pulsating graft.