Table 4.
Effect of adoptive transfer of splenic lymphocytes from FK506-treated LEW rats with ACI heart grafts on the acceptance of ACI hearts by naive LEW recipients
| Group | Spleocyte donor |
Number of Cells (×10a) |
Irradiation (250 rads) |
n | Survival (days) |
MST (days) |
Pa |
|---|---|---|---|---|---|---|---|
| 1b | — | — | − | 7 | 6, 6, 6, 6, 6, 7, 7 | 6.0 | — |
| 2 | — | — | + | 4 | 6, 7, 7, 8 | 7.0 | NS |
| 3 | Normal LEW | 200 | + | 4 | 6, 6, 7, 10 | 6.5 | NS |
| 4 | FK-treated LEW with ACI heart graft (28 days)c |
200 | + | 8 | 6, 7, 8, 8, 10, 10, 10, 15 | 9.0 | <0.01 (0.02) |
| 5 | FK-treated LEW with ACI heart graft (70 days)c |
200 | + | 6 | 7, 7, 7, 10, 10, 20 | 8.5 | 0.01 (0.07) |
a
Wilcoxon rank sum test (Student’s t test).
b
Control values from Table 1.
c
Spleen cells were pooled from 3 animals, each of which had functioning heart grafts for 28 days and more than 70 days.