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. Author manuscript; available in PMC: 2011 Mar 16.
Published in final edited form as: Nature. 2010 Aug 15;467(7313):338–342. doi: 10.1038/nature09367

Figure 1. Examples of known lineage-related genes showing differential DNA methylation between lymphoid and myeloid progenitors.

Figure 1

a, Hematopoietic progenitors included in this study. Dashed-arrow indicates existence of intermediate progenitors. DMR in b, Lck and c, Mpo. Upper panels: top half: CpG methylation (p); lower half: CpG dinucleotides (black tick marks), CpG density (curve), CpG islands (orange lines) and the gene annotation (see online Methods). Middle panels: methylation of individual CpGs (in the red boxes), mean values connected by lines. Bottom panels: mRNA expression levels, normalized to the highest expression among the populations (mean ± s.d., n=3; 5 for MPPFL− for microarrays).