Table 1.
Potency Values and Curve Slopes of IL-6 Preparations From Different Sources
| |
|
Potency (LU/mL) |
|
|
Curve slope |
||
|---|---|---|---|---|---|---|---|
| IL-6 Preparation | n | Mean log10 | (SD) | Potency (LU/mL) Mean antilog | Potency (IU/mL) | Mean | (SD) |
| 88/514a | 16 | 5.1348 | (0.105) | 136,390 | 130,000a | −0.9663 | (0.244) |
| 905734 | 13 | 5.4215 | (0.086) | 263,940 | 251,371 | −0.9671 | (0.221) |
| Sigosix | 10 | 7.4877 | (0.074) | 3.07 × 107 | 2.92 × 107 | −0.9971 | (0.305) |
| L093-PD01 | 5 | 8.8919 | (0.095) | 7.79 × 108 | 7.42 × 108 | −1.0252 | (0.374) |
a
World Health Organization IL-6 International Reference Reagent with an assigned value of 130,000 IU, such that the sensitivity (IU/LU) of the bioassay is 0.95.
Abbreviations: IL-6, interleukin-6; n, number of titrations; SD, standard deviation.