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. 2009 Jun;29(6):333–338. doi: 10.1089/jir.2008.0072

FIG. 1.

FIG. 1.

PRBC supernatant potentiates LPS-induced proinflammatory cytokine release by PBMCs. (A) The amount of IL-1β secreted from PBMCs exposed to control media, Day 1 non-leukoreduced PRBC supernatant (D1 NLR), or Day 42 non-leukoreduced PRBC supernatant (D42 NLR) is shown as a scatter plot with the mean represented by a bar. D42 NLR PRBC supernatant significantly increased IL-1β secretion versus control and D1 NLR supernatant (*P < 0.05 vs. Ctl and D1 NLR; n = 4 for control, n = 15 for D1 NLR and n = 16 for D42 NLR). (B) D42 NLR supernatant exposure resulted in increased TNF-α versus control and significantly increased IL-6 (C) versus control and D1 NLR PRBC supernatant (*P < 0.05 vs. Ctl and D1 NLR groups). (D) IL-10 levels were not different between groups.