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. 2010 Oct 18;5(10):e13460. doi: 10.1371/journal.pone.0013460

Figure 4. Pseudovirion neutralization assay titers at day 28 and day 112 after immunizations at day 0 and boost at day 14.

Figure 4

Nanopatch™ doses were 300 ng (SD = 120), 55 ng (SD = 6.0), 5.7 ng (SD = 1.6) and 0.43 ng (SD = 0.084). Intramuscular doses were 10 µg, 1 µg, 100 ng, 10 ng, and 1 ng. At day 28, Nanopatch™ 300 ng and 55 ng dose groups have reached comparable virus neutralizing titers to all intramuscular injection groups (p<0.05). By day 112, all Nanopatch™ doses have reached comparable neutralizing titres against all intramuscular injection groups (p<0.05). Replicates are staggered in x axis to aid in visualization. Unimmunized plotted at a dose of 0.05 ng due to log scale.