Table 6. Specific messenger RNA fold change linked to increased levels of miR-195 in U-87 astrocytoma RISC.

Name	Entrez gene name	Fold Change	Role in cell	Canonical pathway/Biological process	Entrez gene summary
FRAS1	Fraser syndrome 1	−2.270	unknown	cell communication	This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants.
TRHDE	thyrotropin-releasing hormone degrading enzyme	−2.170	signaling	glutathione metabolism, proteolysis, signal transduction, cell-cell signaling	This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.
RTN1	reticulon 1	2.470	apoptosis	signal transduction, neuron differentiation	This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.