Table 2. Characteristics of case-control studies included in a meta-analysis of the association between the LOC387715 gene polymorphisms and AMD.

Ref	Year	Region, country study was conducted	Ethnicity	Study design composition in cases (% males)	Sex	Mean age (years)		Cases	Controls	Number of eligible subjects
						Cases	Controls			Cases	Controls
[106]	2007	Japan	East Asian	Case-control	79.5	75.7	71.2	Wet AMD	Hospital-based controls without retinal diseases and AMD on the base of full ophthalmologic examination	73	94
[95]	2007	USA	Caucasian	Case-control	NR	>68.0	>68.0	Wet AMD+Dry AMD	Without AMD on the base of full ophthalmologic examination	431	280
[99]	2007	France	Caucasian	Case-control	NR	>65.0	>65.0	Wet AMD	Without any type of drusen, geographic atrophy, or exudative AMD.	118	116
[96]	2007	USA	Caucasian	Case-control	NR	71.3	72.8	Wet AMD	Without AMD on the base of full ophthalmologic examination	134	134
[100]	2007	UK	Caucasian	Case-control	40.6	>65.0	>65.0	Wet AMD	Without AMD on the base of full ophthalmologic examination	401	266
[108]	2008	India	Indian Asian	Case-control	NR	68.8	64.4	Wet AMD+Dry AMD	Ethnic matched controls, without a family history of AMD or any other ocular or systemic diseases	193	203
[3]	2008	China	East Asian	Case-control	58.7	66	66.1	Wet AMD	Without any AMD and any other major eye diseases aside from mild age-related cataracts	121	132
[84]	2005	Germany	Caucasian	Case-control	NR	NR	NR	Wet AMD+Dry AMD	Without any AMD and any other major eye diseases	759	594
[84]	2005	Germany	Caucasian	Case-control	35.1	75.01	68.25	Wet AMD+Dry AMD	Unrelated controls without any AMD and any other major eye diseases	361	328
[133]	2006	USA	Caucasian	Case-control	42	79.5	76.5	Wet AMD+Dry AMD	Without AMD on the base of full ophthalmologic examination	693	172
[133]	2006	USA	Mixed	Case-control	44	73.2	70.3	Wet AMD+Dry AMD	Without AMD on the base of full ophthalmologic examination	120	995
[56]	2007	Russia	Caucasian	Case-control	27.7	72.6	71.1	Wet AMD+Dry AMD	Free of macular changes	155	151
??	2007	Japan	East Asian	Case-control	70.5	73.4	73.6	Wet AMD	Without any AMD	95	99
??	2007	USA	Caucasian	Nested case-control	35.2	60.1	60.2	Wet AMD+Dry AMD	Within 1 year of the same age with cases, and underwent eye examination in the past 2 years	445	1041
[128]	2007	USA	Caucasian	Case-control	42.6	79	72	Wet AMD+Dry AMD	AMD free controls	399	329
[13]	2007	Australia	Caucasian	Cohort	39.9	75.6	74.9	Wet AMD+Dry AMD	AMD free controls	278	557
[93]	2007	USA	Caucasian	Case-control	NR	NR	NR	Wet AMD	Without any AMD	87	232
[83]	2008	USA	Caucasian	Case-control	39.6	79.1	72.9	Wet AMD+Dry AMD	Without AMD on the base of full ophthalmologic examination	164	155