Table 3. The association between the HTRA1 gene polymorphisms and AMD—- Allele and genotype frequencies of case-control studies included in a meta-analysis.
|
Ref |
Year |
Genotype distribution |
AA / GG |
AG / GG |
A / G |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
cases |
controls |
||||||||||||||||
|
N |
AA |
AG |
GG |
P value for HWE |
N |
AA |
AG |
GG |
P value for HWE |
OR1 |
95% CI |
OR2 |
95% CI |
OR |
95% CI |
||
| [101] |
2006 |
96 |
44 |
40 |
18 |
0.266 |
130 |
14 |
59 |
57 |
0.976 |
9.952 |
4.465~22.184 |
2.147 |
1.104~4.174 |
3.626 |
2.450~5.368 |
| [98] |
2007 |
242 |
67 |
108 |
67 |
0.247 |
157 |
8 |
50 |
99 |
0.877 |
12.375 |
5.583~27.432 |
3.192 |
2.022~5.039 |
3.723 |
2.693~5.158 |
| [102] |
2007 |
164 |
68 |
77 |
19 |
0.924 |
106 |
15 |
63 |
28 |
0.104 |
6.681 |
2.980~14.979 |
1.801 |
0.921~3.523 |
2.37 |
1.664~3.375 |
| [105] |
2007 |
123 |
45 |
55 |
26 |
0.488 |
133 |
22 |
57 |
54 |
0.582 |
4.248 |
2.127~8.487 |
2.004 |
1.103~3.640 |
2.231 |
1.566~3.178 |
| [106] |
2007 |
73 |
29 |
39 |
5 |
0.239 |
94 |
16 |
40 |
38 |
0.627 |
13.775 |
4.520~41.984 |
7.41 |
2.642~20.786 |
3.189 |
2.029~5.013 |
| [95] |
2007 |
457 |
102 |
183 |
172 |
<0.001 |
280 |
11 |
90 |
179 |
0.997 |
9.65 |
5.006~18.601 |
2.112 |
1.525~2.937 |
2.937 |
2.299~3.753 |
| [99] |
2007 |
118 |
32 |
57 |
29 |
0.937 |
116 |
5 |
41 |
70 |
0.948 |
15.448 |
5.476~43.582 |
3.356 |
1.860~6.055 |
3.734 |
2.498~5.583 |
| [96]* |
2007 |
134 |
43 |
54 |
37 |
0.0837 |
134 |
21 |
43 |
70 |
0.0111 |
3.874 |
2.009~7.469 |
2.376 |
1.350~4.180 |
2.358 |
1.657~3.347 |
| [100] |
2007 |
401 |
106 |
172 |
123 |
0.019 |
266 |
6 |
91 |
169 |
0.296 |
24.274 |
10.327~57.057 |
2.597 |
1.841~3.664 |
3.826 |
2.963~4.942 |
| [97]* |
2008 |
776 |
131 |
400 |
245 |
0.327 |
294 |
10 |
128 |
156 |
0.0282 |
8.341 |
4.253~16.360 |
1.99 |
1.500~2.640 |
2.042 |
1.652~2.525 |
| [103] |
2008 |
95 |
53 |
33 |
9 |
0.53 |
90 |
19 |
47 |
24 |
0.903 |
7.439 |
2.940~18.819 |
1.872 |
0.772~4.541 |
3.046 |
1.973~4.703 |
| [104] |
2008 |
163 |
94 |
51 |
18 |
0.0379 |
183 |
38 |
90 |
55 |
0.994 |
7.559 |
3.398~14.509 |
1.732 |
0.919~3.262 |
3.31 |
2.403~4.559 |
| [108] |
2008 |
229 |
90 |
89 |
50 |
0.0111 |
184 |
21 |
85 |
78 |
0.956 |
6.686 |
3.695~12.098 |
1.633 |
1.028~2.595 |
2.701 |
2.033~3.589 |
| Total | 3071 | 2167 | |||||||||||||||
* Hardy–Weinberg disequilibrium in case and/or control group