Figure 2. MEMRI experiments demonstrate that the axonal transport deficits in WT-STZ mice recover in SOD2-STZ mice.

(A) Pseudo-color MRI images depicting changes in Mn²⁺ signal intensities (yellow color) at the beginning (2minutes) and at the end of the imaging session (32 minutes) at a region of interest (ROI) identified as a circle on the outer olfactory neuronal layer (ONL). Note that the WT, SOD and SOD2-STZ mice exhibit a change from green (2 minute time point) to yellow (32 minute time point) whereas the WT-STZ animals exhibit a light green color at both time points indicating that Mn²⁺ has not traveled to these areas at the same rate. (B) Gray-Scale Image of the same data set in (A). (C) The graph depicts normalized axonal transport rates (% control) in the WT and SOD2 mice treated with vehicle or STZ for a week before in vivo axonal transport studies. Twelve mice were used in the WT group and four mice were used in each of WT-STZ, SOD2, and SOD2-STZ groups. Statistical analysis: One way ANOVA, Dunnett's post-test. * p<0.05. SOD2  =  SOD-2 overexpressing mice; SOD2-STZ  =  SOD-2 overexpressing mice treated with STZ.