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. 2010 Oct 18;5(10):e13463. doi: 10.1371/journal.pone.0013463

Figure 5. Phosphorylated Tau significantly increase in WT-STZ mice and recovers in SOD2-STZ mice, despite hyperglycemia.

Figure 5

Western blotting analysis of OB tissues from WT, WT-STZ, SOD2, SOD2-STZ mice show: (A) changes in site-specific phosphorylation of tau (p-tau) at threonine 205, (seven mice in WT, WT-STZ groups and six in SOD2 and SOD2-STZ groups) (B) changes in total levels of tau protein, (seven mice in WT, WT-STZ groups and six in SOD2 and SOD2-STZ groups) (C) QPCR of brain homogenates depict relative changes in mRNA levels of tau, (six mice used in each of the four groups) and (D) representative western blot from OB homogenates from 1 week vehicle or STZ treated 2-4-month-old mice. The results are normalized to β-actin. Statistical analysis: One way ANOVA followed by Dunnett's post test. ** p<0.01, *p<0.05.