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. 2010 Oct 18;5(10):e13468. doi: 10.1371/journal.pone.0013468

Figure 6. Effect of AAV-treatment on motor performance of GM1 mice.

Figure 6

(A) Rotarod testing was performed prior to injection (0 months), and then at 1, 2.5, 4, and 6 months post-injection in AAV-T GM1 mice (•), AAV-TC GM1 (✗), untreated GM1 (▴), and HZ mice (⧫). Open-field testing measured (B) locomotor and (C) rearing activity at 2.5 (2.5M) and 4 (4M) months post-injection in HZ (white bars), untreated GM1 (black bars), AAV-T GM1 (light gray bars), and AAV-TC GM1 (dark gray bars) mice. Group sizes: n = 20–24 for 0 and 1 month time points; n = 14–18 for 2.5 and 4 month time points; n = 10–12 for 6 month time point. Graphs represent the mean for each group at the specified time point. Error bars correspond to 1 SEM. * p<0.05 in paired Student's t-test.