Table 4.

Changes in organ function, mRSS, and mHAQ-DI after HDIT

Parameter	Months after HDIT	No. patients	Median difference from baseline	P
mRSS	3	15	− 7 (1 to − 25)	.002
	12	12	− 13 (− 8 to − 19)	.0005
	24	5	− 19 (− 10 to − 32)	.06
	36	3	− 21 (− 17 to − 37)	.25
mHAQ-DI	3	14	− 1.0 (0 to − 2)	.001
	12	11	− 1.675 (0 to − 2.26)	.002
	24	5	− 1.875 (− .125 to − 2.01)	.06
	36	3	− 2.01 (− 2 to − 2.125)	.25
Serum creatinine	3	15	0.1 (− 0.1 to 0.6)	.02
	12	11	0.1 (− 0.1 to 0.8)	.02
	24	5	0.3 (0.2 to 0.7)	.06
	36	2	0.5 (0.2 to 0.8)	.50
DLCO	3	15	− 11 (− 32 to 3)	.001
	12	12	− 5 (− 26 to 7)	.11
	24	5	− 4 (− 22 to 10)	.88
	36	3	4 (− 28 to 12)	1.0
FVC	3	16	1 (− 16 to 7)	.87
	12	12	4 (− 12 to 13)	.10
	24	5	3 (− 2 to 16)	.19
	36	3	− 2 (− 17 to 24)	1.0
LVEF	3	12	− 2 (− 17 to 5)	.02
	12	8	− 0.5 (− 12 to 5)	.81
	24	2	− 2.5 (− 6 to 1)	1.0
	36	2	0 (− 3 to 3)	1.0

mRSS indicated modified Rodnan skin score expressed as points on a scale of 0–51. mHAQ-DI expressed as points on a scale of 0–3. A baseline mHAQ-DI score was not obtained on patient 13. Serum creatinine was expressed in μg/dL. Carbon monoxide diffusing capacity was corrected for hemoglobin; percentage predicted. Forced vital capacity, percentage of predicted. Left ventricular ejection fraction, percentage.