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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Hepatol. 2010 May 27;53(3):460–467. doi: 10.1016/j.jhep.2010.03.019

Table 2.

Pharmacokinetic parameter estimates.

Patient
No.		 Genotype FD/ Vd7
[SE]
(ng/ ml)		 FD/ Vd84
[SE]
(ng/ ml)		 ka7
[ SE]
(1/ day)		 ka84
[SE]
(1/day)		 ke7
[SE]
(1/day)		 ke84
[SE]
(1/day)		 tmax7a
[SE]
(day)		 tmax84a
[SE]
(day)		 C7a max
[SE]
(ng/ml)		 Cmax84a
[SE]
(ng/ml)
1 3 12.8 [3.3] 9.1 [0.8] 0.46 [0.22] 0.68 [0.12] 0.17 [0.09] 0.10 [0.01 ] 3.4 3.3 7.2 6.6
2 3 10.1 [0.9] 9.6 [0.5] 1.61 [0.30] 1.74 [0.27] 0.11 [0.04] 0.09 [0.01 ] 1.8 1.8 8.3 8.1
3 3 15.0* NF 2.40 [0.64] NF 0.10 [0.04] NF 1.4 NF 13.1 NF
6 3 15.7 [7.7] 5.3 [1.6] 0.51 [0.23] 1.39 [1.19] 0.51 [0.17] 0.08 [0.03 ] 2.0 2.2 5.8 4.4
7 3 LSE 29.9 [4.4] LSE 0.34 [0.08] LSE 0.26 [ 0.04] 3.4 12.6
4 1 36.8 [8.1] 28.4 [8.3] 0.73 [0.64] 0.82 [0.37] 0.32 [0.07] 0.21 [0.06] 2.0 2.2 19.4 17.7
5 1 15.5 [1.7] 20.5 [2.5] 2.42 [0.78] 1.19 [0.27] 0.07 [0.03] 0.19 [0.03 ] 1.5 1.8 14.0 14.4
Median
(IQR)		 15.0 (3.5) 15.0 (20.6) 1.27 (1.88) 1.00 (0.88) 0.11 (0.25) 0.14 (0.13 ) 2.0 (0.9) 2.1 (1.5) 11.3 (8.5) 10.4 (9.2)
8 3 6.90 [2.7] 7.0 [1.0] 2.54 [0.98] 2.01 [0.91] 0.05 [0.17] 0.09 [0.02 ] 1.6 1.6 6.4 6.1
9 3 15.1 [1.9] 15.4 [1.5] 1.26 [0.31] 1.26 [0.24] 0.16 [0.04] 0.16 [0.02 ] 1.9 1.9 11.2 11.4
1 3 3 16.2 [0.8] 24.4 [3.5] 3.04 [0.85] 1.14 [0.28] 0.03 [0 03] 0.23 [0.04 ] 1.5 1.8 15.4 1 6.4
1 0 1 12.8 [0.6] 15.4 [1.5] 2.60 [0.57] 1.64 [0.37] 0.06 [0.03] 0.16 [0.02 ] 1.5 1.6 11.7 12.0
1 1 1 12.9 [3.1] 14.0 [0.1] 1.8 [0.81] 1.09 [0.03] 0.07 [0.06] 0.13 [0.001 ] 1.9 2.2 11.4 10.5
1 2 1 16.2 [4.1] 21.9 [5.1] 1.29 [0.58] 0.79 [0.28 0.10 [0.07] 0.21 [0.05 ] 2.2 2.3 13.1 13.5
1 4 1 13.8 1.7] 15.2 [1.9] 1.86 [0.60] 1.62 [0.51] 0.09 [0.04] 0.13 [0.02 ] 1.7 1.7 11.8 12.2
1 5 1 6.91 [1.5] NF 1.35 [0.36] NF 10−5 [0.07] NF 3.7 NF 6. 6 NF
1 6 1 23.5 [5.8] 24.4 [3.5] 1.07 [0.47] 1.14 [0.28] 0.34 [0.16] 0.23 [0.04 ] 1.6 1.8 13.7 16.4
1 7 1 21.6 [2.0] 19.4 [2.0] 0.92 [0.14] 1.08 [0.20] 0.24 [0.03] 0.19 [0.02 ] 2.0 2.0 13.5 13.5
1 8 1 ND N D ND ND ND ND ND N D ND ND
1 9 1 15.0* 16.4 [2.3] 0.37 [0.02] 0.33 [0.07] 0.08 [0.01] 0.10 [0.02 ] 5.3 5.2 9.8 9.8
2 0 1 11.8 [0.7] 11.9 [0.1] 4.21 [1.08] 3.88 [1.21] 0.05 [0.02] 0.10 [0.01 ] 1.1 1.0 11.2 10.9
2 1 1 23.2 [1.2] NF 9.90 [2.97] NF 0.16 [0.03] NF 0.4 NF 21.7 NF
Median
(IQR)		 15.0 (6.5) 15.4 (7.9) 1.80 (1.66) 1.14 (0.56) 0.08 (0.11) 0.16 (0.11 ) 2.0 (0.6) 1.8 (0.6) 12.1 (3. 1 ) 11.9 (3.0)
p value NS NS NS NS NS NS NS NS NS NS
*

fixed due to large standard error [SE]; NF, Eq. 3 cannot be fitted due to continuous decline (patients 3 and 15) or large fluctuations (patient 21) of interferon-alpha concentration; ND, IFN concentration remained below 0.2 ng/ml during the first 7 days; LSE, large standard error. IQR, interquartile range, the difference between the third and first quartile;

a

calculated by Eq. 2; NS, not significant.