Skip to main content
. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Mech Ageing Dev. 2010 Sep 9;131(10):641–649. doi: 10.1016/j.mad.2010.08.010

Fig 5. Pathway analysis of genes that showed persistent up- or downregulation durng juvenile growth and aging.

Fig 5

Ingenuity Pathway Analysis (IPA 7.1) was applied to genes that showed coordinate up- or downregulation during juvenile growth in multiple organs of mice and rats and also persistent changes in expression during aging (P < 0.05) in liver (hatched bars), kidney (solid grey bars), or lung (solid black bars). The 5 most overrepresented molecular, cellular, or physiological functions are shown. Cell cycle, DNA replication, and cellular growth and proliferation were amongst the most overrepresented functions in kidney and lung, suggesting that genes implicated in postnatal growth that continue to decline during aging were involved in cell proliferation.