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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Eur J Neurosci. 2010 Sep 16;32(8):1310–1318. doi: 10.1111/j.1460-9568.2010.07373.x

Figure 1.

Figure 1

Tonic GABA current decreases with postnatal development when recorded in the presence of exogenous GABA. A. Representative voltage clamp recordings of GABAAR mediated tonic current from L5 neocortical pyramidal cells in P4, P10 and P34 mice in the presence of 5 μM GABA. B. Summary plot of mean tonic current recorded from neocortical pyramidal cells representing three postnatal age groups. Mean tonic current substantially decreases from the first to the second week of postnatal life then remains stable one month after birth. C. Summary plot of the change in the standard deviation of the baseline holding current before and after GABAAR blockade. The percent decrease in standard deviation is greater in neonates than juveniles and mature mice. Data are shown as mean ± S.E.M. (one-way ANOVA, Tukey post hoc: *, p < 0.01).