Table 3.
Summary of 14C Radioactivity Pharmacokinetic Parameters in Urine, Feces, and Expired Air: Study 1
| Parameter | 10-mg IV dose (n = 6) | 20-mg oral dose (n = 4a) | ||||
|---|---|---|---|---|---|---|
| Urine | Feces | Expired air | Urine | Feces | Expired air | |
| Ae,b μg | 9720 | 165.0 | 0 | 490.0 | 19,030 | 5 |
| Fe, % | 97.2 | 1.65 | 0 | 2.45 | 95.1 | 0.03 |
| Mass balance, % (SD) | 98.9 (2.1) | 97.6 (1.5) | ||||
a
Two subjects did not receive oral dose of study drug because they were withdrawn from the study.
b
Ae, total amount of 14C radioactivity excreted in urine or feces, or estimated total amount of 14C radioactivity excreted in expired air; Fe, percentage of dose of 14C radioactivity excreted in urine, feces, or expired air; IV, intravenous; SD, standard deviation.