Table 4.

Summary of Pharmacokinetic Parameters and ¹⁴C Radioactivity of FDKP in Plasma: Study 1

Parametera	Intravenous dose (10 mg) n = 6	Oral dose (20 mg) n = 4
AUC0−∞, ng/ml·min	75,240 (5640)	NC
AUC0−tlast, ng/ml·min	74,791 (5640)	5,587 (3028)
Cmax, ng/ml	722.7 (130.5)	8.5 (1.6)
tmax, h	NC	6 (1, 16)
t1/2, min	150 (24)	NC
Foral	NA	0.0364 (0.0174)

^aParameters are presented as mean (standard deviation) except for t_max, which is presented as median (min, max).

AUC_0–tlast, area under the plasma concentration–time curve from time 0 to t, where t is time of last quantifiable concentration; F_oral, bioavailability following oral dose; NA, not applicable; NC, not calculated.