Table 6.
Geometric Mean (% Coefficient of Variation) FDKP Pharmacokinetic Parameters in Diabetic Nephropathy: Study 2
| Parameter | Diabetic without DNP (n = 12) | Diabetic nephropathy | ||
|---|---|---|---|---|
| Mild (n = 15) | Moderate (n = 9) | Mild and moderate (n = 24) | ||
| AUC0–480, ng/ml·min | 30,474 (32) | 36,090 (43) | 38,206 (54) | 36,869 (47) |
| AUC0−∞, ng/ml·min | 37,137 (29) | 44,168 (43) | 56,393 (58) | 48,406 (53) |
| Cmax, ng/ml | 147.0 (44) | 184.1 (55) | 126.4 (66) | 159.9 (59) |
| tmax, mina | 12 (3–45) | 15 (3–76) | 30 (9–153) | 16 (3–153) |
| t1/2, min | 190.6 (52) | 196.2 (46) | 269.8 (65) | 223.8 (64) |
| Ae0–1440, mgb | 3.7 (1.2) | 3.7 (1.7) | 2.8 (1.7) | 3.3 (1.7) |
a
tmax is presented as median (range).
b
Ae is presented as arithmetic mean (standard deviation).