Table 7.
Geometric Mean (% Coefficient of Variation) FDKP Pharmacokinetic Parameters in Chronic Liver Disease: Study 3
| Parameter | Normal (n = 12) | Chronic liver disease | ||
|---|---|---|---|---|
| Mild (n = 15) | Moderate (n = 6) | Mild and moderate (n = 21) | ||
| AUC0–480, ng/ml·min | 26,710 (35) | 31,001 (26) | 32,700 (36) | 31,477 (29) |
| AUC0−∞, ng/ml·min | 32,320 (33) | 36,505 (26) | 40,085 (41) | 37,494 (32) |
| Cmax, ng/ml | 143.4 (49) | 161.5 (35) | 156.8 (42) | 160.2 (36) |
| tmax, mina | 7.5 (3–20) | 6.0 (3–60) | 6.0 (3–45) | 6.0 (3–60) |
| t1/2, min | 190 (27) | 173 (30) | 198 (45) | 180 (36) |
| Ae0–1440, mgb | 3.2 (1.1) | 4.5 (2.7) | 3.4 (1.2) | 4.1 (2.4) |
a
tmax is presented as median.
b
Ae is presented as arithmetic mean (standard deviation).