Fig. 1.

Genotype to phenotype correlation of ferroportin disease: patients with ferroportin disease identified from the systematic meta-analysis were grouped according to the SLC40A1 mutation. Box-Whisker blots of (A) serum ferritin, and (B) transferrin saturation in mutations reported in more than 5 patients are shown. Boxes represent 25th and 75th percentile, Whiskers range and horizontal lines represent the median. Outliers are shown as circles. Grey, dark blue, and light blue boxes indicate that all patients reported with the respective mutation were classified as classical, non-classical, or variable biochemical phenotype, respectively, i.e. all patients had low or normal transferrin saturation (grey), increased transferrin saturation (dark blue), or different patients with the same mutation had variable transferrin saturation (light blue). Any outliers are marked with a circle and extreme cases with an asteriks.