Table 2.
Genetic associations with CAD/MI identified by GWA studies in the general population.
| Representative SNP | Closest Gene(s) | Chromosome | Position (Mb) | Risk allele | OR | 95% CI | Reference |
|---|---|---|---|---|---|---|---|
| rs11206510 | PCSK9 | 1 | 55.3 | T | 1.15 | 1,10–1.21 | (40) |
| rs646776 | CELSR2-PSRC1-SORT1 | 1 | 109.6 | T | 1.19 | 1.13–1.26 | (40;42;44) |
| rs17465637 | MIA3 | 1 | 220.8 | C | 1.14 | 1.10–1.19 | (40;42;44) |
| rs6725887 | WDR12 | 2 | 203.5 | C | 1.17 | 1.11–1.23 | (40) |
| rs9818870 | MRAS | 3 | 139.6 | T | 1.15 | 1.11–1.19 | (38) |
| rs12526453 | PHACTR1 | 6 | 13.0 | C | 1.12 | 1.08–1.17 | (40) |
| Haplotype | SLC22A3- LPAL2- LPA | 6 | 160.7 | CCTC | 1.82 | 1.57–2.12 | (43) |
| Haplotype | SLC22A3- LPAL2- LPA | 6 | 160.7 | CTTG | 1.20 | 1.13–1.28 | (43) |
| rs4977574 | CDKN2A/CKN2B | 9 | 22.1 | G | 1.29 | 1.25–1.34 | (39-42;44) |
| rs1746048 | CXCL12 | 10 | 44.1 | C | 1.17 | 1.11–1.24 | (40;42;44) |
| rs2259816 | HNF1A-C12orf43 | 12 | 119.9 | T | 1.08 | 1.05–1.11 | (38) |
| rs1122608 | LDLR | 19 | 11.0 | G | 1.15 | 1.10–1.20 | (40) |
| rs9982601 | MRPS6-SLC5A3-KCNE2 | 21 | 34.5 | T | 1.20 | 1.14–1.27 | (40) |