Table 1.

Precision and accuracy of sorafenib and sorafenib N-oxide in human plasma.

	Sorafenib (ng/mL)				Sorafenib N-oxide (ng/mL)
	150	800	8000	80000 (1:10 dilution)	30	200	2000	20000 (1:10 dilution)
Accuracy
Mean (ng/mL)	147	771	8088	80161	28.5	190	2103	20929
SDa	2.2	8.9	145	2509	1.8	12.5	157	1367
DEVb (%)	−2.0	−3.6	1.1	0.2	−5.1	−5.3	5.1	4.6
Precision
Within-run (%)	1.2	0.9	1.6	0.2	6.5	6.9	6.2	0.5
Between-run (%)	1.1	0.8	1.0	0.3	*	*	4.6	0.5

^aSD: standard deviation;

^bDEV: deviation from the nominal value;

^*No significant variation was observed as a result of performing the assay in different runs.