Figure 12. SDF-1 α reduces evoked field responses at the entorhinal cortex–CA1 synapse via CXCR4 activation.

A, summary plot showing the effect of SDF-1 α application (black bar) on evoked field potentials. Field responses were recorded in stratum lacunosum-moleculare after stimulation of the direct entorhinal cortex–CA1 pathway. Insets show averaged field responses in control (1), during the application of SDF-1 α (2) and superimposed (1, 2). B, as in A but in the constant presence of the CXCR4 antagonist AMD3100. Notice the lack of effect of SDF-1 α application. Gabazine present throughout (12.5 μm) both in A and B.