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. 2010 Jun 15;18(9):1675–1682. doi: 10.1038/mt.2010.123

Figure 1.

Figure 1

Designing and cloning of the U1-antisense-RNA molecules. (a) Schematic representation of the chimeric U1-antisense snRNA. The grey box indicates the location of the antisense sequences. (b) Table summarizing the 10 different constructs produced together with the corresponding target regions on exon 51 and flanking intron sequences (uppercase – exonic regions; lowercase – intron sequences). Costructs ESE A and ESE A* contains the sequences (indicated in italics) currently utilized in the Prosensa17 and AVI Biopharma18 clinical trials, respectively.