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. 2010 Jul 5;588(Pt 16):3063–3074. doi: 10.1113/jphysiol.2010.191080

Figure 1. The mGluR1 sEPSC is enhanced by inhibition of AMPA/KARs.

Figure 1

A, plot of the amplitude of the first AMPA response of the train (/AMPA1, filled symbols) and mGluR sEPSC (open symbols) as a function of time. Bars indicate time of application. B, average of 4 (control) or 5 (NBQX and CPCCOEt) postsynaptic responses to burst stimulation of parallel fibres (10 at 100 Hz) in a transverse slice. Ba, black trace in control, dotted grey trace after addition of 1 μm NBQX and dotted black trace after further addition of 100 μm CPCCOEt. In the presence of NBQX the fast AMPA current is quickly blocked and the mGluR sEPSC becomes visible. Upon application of CPCCOEt the mGluR sEPSC is fully blocked. The open rectangle denotes the time window used to measure the average amplitude of ImGluR plotted in A. Bb, same traces at higher magnification to emphasise the mGluR sEPSC. C, average mGluR sEPSC ±s.e.m.*Data significantly different from control, P < 0.01.