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. Author manuscript; available in PMC: 2010 Oct 19.
Published in final edited form as: J Immunol. 2004 Apr 1;172(7):4111–4122. doi: 10.4049/jimmunol.172.7.4111

FIGURE 4.

FIGURE 4

Effects of previous exposure of 4T1 tumor to IL-12 on its progression in naive mice. 4T1 tumor cells were implanted in BALB/c mice with or without IL-12 treatment. On day 28, primary tumors were removed surgically and digested with collagenase to make single-cell suspension and to remove nontumor cells. These purified tumor cells were then injected into naive mice and monitored for their growth (a) without any treatment. On day 28, mice were sacrificed, and lung metastasis was measured (b). The p value of the bracketed statistical comparison is indicated.