Table IV.

IFN-γ-independent genes inhibited by IL-12 (two genes)^a

Common Name	Genbank	Map	WT—IL12- Treated	GKO—Not Treated	GKO—IL12- Treated	Function
Decysin	AJ242912	Unknown	5.93	2.64	6.67	Metalloprotease
CCP5	X56990	14	3.07	0.92	2.87	Cytotoxic cell protease

^aGenes are selected based on the following criteria: 1) they must be expressed two times less than the controls (untreated wild type or GKO) to qualify as IL-12-inhibited genes; 2) their expression detection must be statistically valid as present with detection p < 0.05; 3) IFN-γ-dependent genes are defined as those whose expression must be inhibited by IL-12 in GKO mice less than two times compared with untreated GKO mice; and 4) IFN-γ-independent genes are defined as those whose expression must be inhibited by IL-12 in GKO mice greater than two times compared with untreated GKO mice. GenBank accession numbers are given. Chromosomal locations (map) are given when they are known. The numbers in columns 4–6 are relative fold of expression over the baseline (control untreated, wild-type group), which is arbitrarily set as 1. These numbers are negative, meaning that they represent the degree of inhibition of the expression of these genes by the IL-12 treatment, compared with the baseline.