Table 1.

Pharmacokinetics of ¹¹¹In-DOTA-GSG-KCCYSL in ovcar-3 tumor bearing scid mice at different time intervals (n =3).

Tissues	1 h	2 h	2 h block	4 h	24 h
Percent injected dose/gram (%ID/g)
Tumor	0.50 ± 0.05	0.39 ± 0.10	0.16 ± 0.03*	0.15 ± 0.01	0.09 ± 0.03
Blood	0.23 ± 0.07	0.13 ± 0.03	0.10 ± 0.01	0.07 ± 0.00	0.01 ± 0.00
Brain	0.02 ± 0.01	0.01 ± 0.0	0.02 ± 0.01	0.01 ± 0.00	0.01 ± 0.00
Heart	0.12 ± 0.03	0.07 ± 0.01	0.06 ± 0.03	0.04 ± 0.01	0.02 ± 0.00
Lung	0.34 ± 0.02	0.20 ± 0.02	0.18 ± 0.02	0.12 ± 0.03	0.05 ± 0.01
Liver	0.20 ± 0.03	0.22 ± 0.02	0.21 ± 0.07	0.14 ± 0.01	0.07 ± 0.01
Spleen	0.15 ± 0.03	0.12 ± 0.02	0.11 ± 0.02	0.10 ± 0.01	0.06 ± 0.01
Stomach	0.08 ± 0.08	0.21 ± 0.05	0.17 ± 0.05	0.06 ± 0.03	0.03 ± 0.02
Kidneys	3.39 ± 0.58	3.01 ± 0.73	2.93 ± 1.20	2.73 ± 0.18	1.35 ± 0.23
Muscle	0.05 ± 0.01	0.03 ± 0.00	0.05 ± 0.01	0.02 ± 0.00	0.02 ± 0.00
Pancreas	0.08 ± 0.02	0.05 ± 0.01	0.02 ± 0.00	0.02 ± 0.00	0.01 ± 0.01
Bone	0.05 ± 0.01	0.04 ± 0.01	0.06 ± 0.02	0.03 ± 0.02	0.01 ± 0.00
Percent injected dose (%ID)
Urine	95.60 ± 1.06	96.10 ± 1.40	97.0 ± 1.02	96.46 ± 2.29	95.90 ± 1.05
Intestines	0.45 ± 0.10	1.3 ± 0.80		1.70 ± 0.91	1.20 ± 0.57
Uptake ratio of tumor/normal tissue
Tumor/blood	2.17	3.0		2.14	9.0
Tumor/muscle	10.0	13.0		7.5	4.5

Data are presented as %ID/g ± SD except for urine and intestines, values for which are expressed as %ID ± SD.

^*P ≤ 0.02, significance comparison between radiolabeled peptide uptake without and with cold peptide at 2 h post injection.