TABLE 1.
Hamster heart graft survival in LEW rat recipients treated with FK506, BQR, RS-61443, cyclophosphamide, methotrexate, mizoribine, and deoxyspergualin as single agentsa
| Group | Agent | Dose (mg/kg/ day) |
Duration (days) |
n | Survival (days) | Median survival (days) |
|---|---|---|---|---|---|---|
| 1 | — | — | — | 6 | 3, 3, 3, 3, 3, 3 | 3.0 |
| 2 | FK506 | 2.0 | 0 → | 6 | 4, 4, 4, 4, 5, 5 | 4.0 |
| 3 | BQR | 3.0 | −1 → | 4 | 5, 5, 6, 7 | 5.5 |
| 4 | BQR | 4.0 × 3 → 3.0 | −1 → | 6 | 5, 8, 8, 11, 12, >100 | 9.5 |
| 5 | BQR | 4.5 | −1 → | 4 | 7,b 9,b >75, >75 | >42.0 |
| 6 | RS-61443 | 20 | −1 → | 4 | 4, 5, 5, 6 | 5.0 |
| 7 | RS-61443 | 40 | −1 → | 4 | 6, 7, 7, 8 | 7.0 |
| 8 | RS-61443 | 60 × 3 → 40 | −1 → | 6 | 6, 8,b 9, 9, 20, 23 | 9.0 |
| 9 | RS-61443 | 60 | −1 → | 4 | 9, 10, 13, 15 | 11.5 |
| 10 | Cyclophosphamide | 7.5 | −1 → | 5 | 7, 8, 8, 8, 9 | 8.0 |
| 11 | Cyclophosphamide | 10.0 | −1 → | 5 | 14, >15, >15, >15, >15 | >15.0 |
| 12 | Cyclophosphamide | 15.0 | −1 → | 5 | >28, >28, >36, >36, >36 | >36.0 |
| 13 | Methotrexate | 0.5 | −1 → | 5 | 10, 11,b 13,b 14,b >16 | 13.0 |
| 14 | Mizoribine | 7.5 | −1 → | 5 | 4, 4, 4, 4, 5 | 4.0 |
| 15 | DSPG | 5.0 | −1 → | 3 | 4, 4, 4 | 4.0 |
a
BQR, RS-61443, Cyclophosphamide, Methotrexate, Mizoribine and Deoxyspergualin were administered from one day before transplantation and continued until graft rejection.
b
Animal died with functioning graft.