TABLE 3.
Hamster liver graft survival in LEW rat recipients treated with FK506, BQR, RS-61443 and cyclophosphamide as single agents
| Group | Agent | Dose (mg/ kg/day) |
Duration (days) |
n | Survival (days) | Median survival (days) |
1-month survival rate (%) |
100-day survival rate (%) |
|---|---|---|---|---|---|---|---|---|
| 1 | — | — | — | 8 | 6, 7, 7, 7, 7, 7, 7, 8 | 7.0 | 0 | 0 |
| 2 | FK506 | 1.0 | 0–30a | 10 | 7, 11, 18, 19, 21, 48, 58, 72, 94, >100 |
34.5 | 50 | 10 |
| 3 | BQR | 3.0 | 0-Death | 7 | 7, 8, 9, 12, 17, 19, 74 | 12.0 | (5/10) 14.3 |
(1/10) 0 |
| 4 | RS-61443 | 20.0 | 0-Death | 5 | 7, 7, 7, 7, 8 | 7.0 | (1/7) 0 |
0 |
| 5 | Cyclophosphamide | 7.5 | 0-Death | 5 | 7, 7, 9, 9, 9 | 9.0 | 0 | 0 |
a
FK506 was used at a dose of 1.0 mg/kg/day for the first 30 days (0 to 30) and continued at 0.5 mg/kg/day every other day (days 31 to 100).