TABLE 4.
Hamster liver graft survival in LEW rat recipients treated with combination treatment with FK506a
| Group | Agent | Dose (mg/ kg/day) |
Duration (days) |
n | Survival (days) | Median survival (days) |
1-month survival (%) |
|---|---|---|---|---|---|---|---|
| 1 | BQR | 3.0 | 0–13 | 7 | 21, 42, 81, >100, >100, >100, >100 | >100 | 85.7 |
| 2 | BQR | 3.0 | 0–30 | 7 | 13, 21, 23, 32, 36, 46, >100 | 32.0 | (6/7) 57.1 |
| 3 | BQR | 3.0 | 0–13b | 9 | 15, 15, 19, 30, 38, >100, >100, >100, >100 | 38.0 | (4/7) 66.7 |
| 4 | RS 61443 | 20 | 0–13 | 10 | 25, 83, >100, >100, >100, >100, >100, >100, >100, >100 | >100.0 | (6/9) 90.0 |
| 5 | RS 61443 | 20 | 0–30 | 9 | 12, 22, 30, 36, 54, >100, >100, >100, >100 | 54.0 | (9/10) 77.8 |
| 6 | RS 61443 | 30 | 0–13 | 10 | 15, 15, 39, 76, >82, >84, >96, >97, >97, >98 | >83.0 | (7/9) 80.0 |
| 7 | Splenectomy | — | — | 6 | 9, 11, 18, 61, >100, >100 | 39.5 | (8/10) 50.0 |
| 8 | Cyclophosphamide | 7.5 | 0→9 | 10 | 10, 31, >40, >45, >45, >45, >47, >48, >48, >51 | >45.0 | (3/6) 90.0 |
| 9 | Cyclophosphamide | 10.0 | 0→9 | 5 | >32, >32, >32, >39, >39 | >32.0 | (9/10) 100.0 |
| 10 | Cyclophosphamide | 80.0 | −10 | 12 | 12, 13, 20, >46, >47, >47, >47, >47, >65, >66, >66, >66 | >47.0 | (5/5) 75.0 |
| (i.p.) | (once) | (9/12) |
a
FK506 was used at 1.0 mg/kg/day for the first 30 days (0 to 30) and continued at 0.5 mg/kg/day every other day (days 31 to 100).
b
BQR was administered for the first 14 days and continued on alternate days from days 14 to 100 at a dose of 3.0 mg/kg/day.