Table 1.
Baseline demographics.
| GHD | MPHD | TS | SGA | NS | ISS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | |
| Gender, M/F | 2,918/952 | 220/135 | 0/382 | 224/136 | 58/21 | 528/223 | ||||||
| Age, yr | 3,870 | 10.8 ± 3.54 | 355 | 7.5 ± 5.45 | 382 | 8.6 ± 4.03 | 360 | 8.4 ± 3.74 | 79 | 9.6 ± 3.76 | 751 | 11.2 ± 3.06 |
| HSDS | 3,870 | −2.2 ± 0.89 | 355 | −1.9 ± 1.39 | 382 | −2.6 ± 0.9 | 360 | −2.6 ± 0.89 | 79 | −2.7 ± 0.70 | 751 | −2.3 ± 0.75 |
| IGF-I SDS | 3,360 | −2.5 ± 1.42 | 184 | −3.2 ± 1.67 | 220 | −1.9 ± 1.22 | 258 | −2.4 ± 1.68 | 65 | −2.8 ± 1.27 | 701 | −2.2 ± 1.45 |
| Bone age, yrs | 3,369 | 9.3 ± 3.41 | 186 | 8.5 ± 4.5 | 256 | 8.0 ± 3.46 | 296 | 7.3 ± 3.68 | 66 | 8.0 ± 3.75 | 667 | 9.6 ± 3.31 |
| Baseline GH dose, mg/kg/day | 3,514 | 0.047 (0.0121) | 319 | 0.039 (0.0123) | 357 | 0.051 (0.0098) | 325 | 0.052 (0.0137) | 72 | 0.047 (0.0106) | 644 | 0.050 (0.0127) |
| Peak GH, ng/mL | 3,326 | 5.3 ± 2.77 | 202 | 3.1 ± 3.04 | 16 | 18.2 ± 31.54 | 138 | 14.4 ± 13.69 | 32 | 10.8 ± 9.13 | 542 | 17.1 ± 20.09 |
| Baseline HSDS (males) | 2918 | −2.1 ± 0.85 | 220 | −1.9 ± 1.36 | — | — | 224 | −2.5 ± 0.83 | 58 | −2.6 ± 0.69 | 528 | −2.2 ± 0.71 |
| Baseline HSDS (female) | 952 | −2.4 ± 0.97 | 135 | −1.9 ± 1.44 | 382 | −2.6 ± 0.90 | 136 | −2.7 ± 0.97 | 21 | −2.9 ± 0.69 | 223 | −2.4 ± 0.82 |
GHD: idiopathic growth hormone deficiency; MPHD: multiple pituitary hormone deficiency; TS: Turner syndrome; SGA: short for gestational age; NS: Noonan syndrome; ISS: idiopathic short stature.