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Potencies of nucleoside transport inhibitors on human ENTs and PMAT
Values are given as means ± S.D. (n = 3). IC50 values are shown in italics.
| Protein |
Ki or IC50 |
||
|---|---|---|---|
| NBMPR | Dipyridamole | Dilazep | |
| nM | |||
| hENT1 | 0.4 ± 0.1a | 5.0 ± 0.9a | 18.7 ± 2.0b |
| hENT2 | 2800 ± 300a | 356 ± 13a | 134,000 ± 40,000b |
| hENT3 | >10,000c | >1000c | >1000c |
| PMAT | 11,074 ± 2800 | 5901 ± 900 | 10,236 ± 1100 |
IC50 values from Ward et al. (2000).
Ki values from Visser et al. (2002).
Data from Baldwin et al. (2005).
