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Genetic interactions between rad27Δ, mre11-nd, sae2Δ and sgs1Δ mutants. Viability and genotypes of spores derived from diploids heterozygous for the indicated mutations. (A) Deletion of YKU70 suppresses the synthetic lethality/growth defect of rad27Δ mutants with sae2Δ and mre11-nd, but not with rad55Δ. (B) Loss of Yku70 or EXO1 over-expression rescues the sae2Δ sgs1Δ synthetic lethality.
