Fig. 3.

Effects of the expression of SHP-2 constructs on the migration and proliferation of REN and REN-HP cells. Wound-induced migration (A) and cell proliferation (B) were studied in REN and REN-HP cells expressing WT, CS, or 2YF constructs. The expression of CS-SHP-2 abrogated the stimulation of cell motility mediated by the expression of PECAM-1, whereas cell proliferation was not affected by the presence of any of the constructs. Data are presented as means ± SE (n = 3–4, for the proliferation studies; n = 6 for the migration studies; *P < 0.0001). The data presented are representative of least 3 experiments.